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HRID2098989

反应详情

EQUATION

反应方程式

HRID 2098989 的结构方程式

REACTANTS

反应物

2
反应SMILES：N[C@@H](C[13c]1ccccc1)C(=O)O
HCID11062753

未命名化合物

反应SMILES：CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8COCC(C)O)O[C@@H]7COCC(C)O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)O[C@@H]4COCC(C)O)O[C@@H]3COCC(C)O
HCID14049689

6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-β-cyclodextrinr

C63H112O42

PRODUCTS

产物

1
反应SMILES：CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8COCC(C)O)O[C@@H]7COCC(C)O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)O[C@@H]4COCC(C)O)O[C@@H]3COCC(C)O.N[C@@H](C[13c]1ccccc1)C(=O)O
HCID131727548

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
85 °C

PROCEDURE

实验过程

To 5 ml of distilled water, 299 mg of (1-13C]-phenylalanine and 1818, mg hydroxypropyl-β-cyclodextrin (in a molar ratio of 1:1) were added and heated to 85° C. to make a solution. Thus, a solution of (1-13C] phenylalanine/hydroxypropyl-β-cyclodextrin inclusion complex was prepared wherein when this solution was allowed to cool to 25° C., no precipitation of phenylalanine was observed while the solubility of phenylalanine is 148 mg/5 ml at 25° C. On the other hand, if 299 mg of (1-13C]-phenylalanine only was added to 5 ml of distilled water and heated to 85° C. to dissolve, phenylalanine was precipitated when this solution was allowed to cool to 25° C. The increase of solubility of phenylalanine in the presence of hydroxypropyl-β-cyclodextrin confirmed the formation of (1-13C]-phenylalanine/hydroxypropyl-β-cyclodextrin inclusion complex.

WORKUP

后处理

  1. temperatureto cool to 25° C.
  2. customno precipitation of phenylalanine
  3. customat 25° C
  4. additionOn the other hand, if 299 mg of (1-13C]-phenylalanine only was added to 5 ml of distilled water
  5. temperatureheated to 85° C.
  6. dissolutionto dissolve
  7. customphenylalanine was precipitated when this solution
  8. temperatureto cool to 25° C
  9. temperatureThe increase of solubility of phenylalanine in the presence of hydroxypropyl-β-cyclodextrin