Bromine → 1-Bromo-3-chloro-4-ethoxy-2-fluorobenzene

606 g of the compound (b43) was added to a reactor in a nitrogen atmosphere, to which 570 g of bromine was added dropwise over 1 hour in a temperature range of 20 to 40° C., followed by stirring for 30 minutes. The resulting reaction mixture was washed with a saturated sodium thiosulfate aqueous solution, a 10% sodium hydroxide aqueous solution, and water. The resulting reaction mixture having been washed was subjected to fractional distillation under reduced pressure to obtain 760 g of 1-bromo-3-chloro-4-ethoxy-2-fluorobenzene (C2). The resulting compound (C2) was white solid and had a melting point of 65.4 to 66.1° C. and a boiling point of 125 to 127° C./8 mmHg.

1. additionwas added dropwise over 1 hour in a temperature range of 20 to 40° C.
2. customThe resulting reaction mixture
3. washwas washed with a saturated sodium thiosulfate aqueous solution
4. customThe resulting reaction mixture
5. washhaving been washed
6. distillationwas subjected to fractional distillation under reduced pressure

ORD record

ord-ad61beb158bb4b2e95dae3a756733df4

Source dataset

uspto-grants-2009_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07569258B2