HCID 69063340, compound → HCID 69062805, compound

HRID 2099134Notes

Reaction equation

HRID 2099134 reaction equation
[NH2:1][C:2]1[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][CH2:8][C@:7]1([CH3:15])[C:11]([O:13]C)=[O:12])=[O:5]>[OH-].[K+]>[NH2:1][C:2]1[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][CH2:8][C@:7]1([CH3:15])[C:11]([OH:13])=[O:12])=[O:5]

Participants

3

Reactant 1

HCID 69063340HCID 69063340, compound

Product 1

HCID 69062805HCID 69062805, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Conditions

Temperature
50 °C

Procedure

930 mg (3.02 mmol) methyl(R)-1-(2-amino-6-nitro-benzoyl)-2-methyl-pyrrolidine-2-carboxylate are dissolved in 3 mL 20% ethanolic KOH and stirred for 1.5 h at 50° C. Then the solvent is eliminated in vacuo and the crude product is purified by chromatography. The carrier material used is silica gel and the eluant used is dichloromethane, to which 15% of a mixture of 90% methanol and 10% saturated aqueous ammonia solution has been added.

Workup

  1. customthe crude product is purified by chromatography
  2. additionto which 15% of a mixture of 90% methanol and 10% saturated aqueous ammonia solution has been added

Sources & evidence

ORD record
ord-ff3c2990cbed41f9a34ae6f18cd7d2f8
Source dataset
uspto-grants-2009_08
Patent number
US07569561B2

Reaction notes

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