2-Hydrazinopyridine → HCID 11199394, compound

HRID 2099139Notes

Reaction equation

HRID 2099139 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:16](=O)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:7]([C:12]([O:14]C)=O)[N:8]2[CH3:11])=[CH:4][CH:3]=1.[N:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[NH:29][NH2:30]>C(O)C.C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[N:30][N:29]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][N:23]=4)[C:12](=[O:14])[C:7]=3[N:8]([CH3:11])[C:9]=2[CH:10]=1

Participants

5

Reactant 2

HCID 786452-HydrazinopyridineHCID 21948023HCID 21948023, compound

Product 1

HCID 11199394HCID 11199394, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 702EthanolSolvent

Procedure

A solution of 0.40 g (1.36 mmol) of ethyl 6-fluoro-2-(methoxycarbonyl)-1-methyl-α-oxo-1H-indole-3-acetate (obtained in stage 1.4.) in 30 ml of absolute ethanol, a few drops of glacial acetic acid and 0.60 g (5.5 mmol) of 2-pyridinylhydrazine is brought to reflux for 17 h.

Workup

  1. temperatureto reflux for 17 h.

Sources & evidence

ORD record
ord-44593baea79f4f2398906e00993d5047
Source dataset
uspto-grants-2009_08
Patent number
US07569567B2

Reaction notes

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