HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → 6-Chloro-7-iodo-7-deazapurine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-Chloro-7-iodo-7-deazapurine | HCID 14809281 | 82.3% |
Reaction Steps
To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) dissolved in 80 mL of chloroform was added 4.5 grams (0.02 mol) of N-iodosuccinimide and the resulting mixture heated at reflux for 1 hour. After cooling to room temperature, the percipitate was removed by flitration and dried under reduced pressure affording 4.6 grams (82%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569569B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-2b37e7f6295d4bb287d87f41a99e6a36 |
| Source note | uspto-grants-2009_08 |