Morpholine → HCID 86624992, compound

Participants

Reaction Steps

5-Chloro-3-(chloromethyl)-N-pyrimidin-4-yl-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine (300 mg, 0.7 mmol), morpholine (185 mg, 2.1 mmol) and N,N-diisopropylethylamine (270 mg, 2.1 mmol) were mixed in methyl sulfoxide (2 ml) in a reaction vial. The reaction mixture was stirred 18 hours at room temperature and then purified on reverse phase HPLC and lyophilized to give 5-chloro-3-(morpholin-4-ylmethyl)-N-pyrimidin-4-yl-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine trifluoroacetate (350 mg).

Provenance & Evidence