2,4-Dichlorobenzylamine → HCID 57794153, compound

HRID 2099317Notes

Reaction equation

HRID 2099317 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([O:13][CH2:14][C@H:15]([CH3:16])[N:8]3[CH:7]=[C:6]([C:17](O)=[O:18])[C:5]2=[O:20])[C:11]=1[F:12].[Cl:21][C:22]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:23]=1[CH2:24][NH2:25]>>[Cl:21][C:22]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:23]=1[CH2:24][NH:25][C:17]([C:6]1[C:5](=[O:20])[C:4]2[C:9]3=[C:10]([O:13][CH2:14][C@H:15]([CH3:16])[N:8]3[CH:7]=1)[C:11]([F:12])=[C:2]([F:1])[CH:3]=2)=[O:18]

Participants

3

Reactant 2

HCID 14852,4-DichlorobenzylamineHCID 688333Levofloxacin q-acid

Product 1

HCID 57794153HCID 57794153, compound

Procedure

The compound is prepared in analogy to the instructions of Example 37A, from (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (for preparation: see Journal of Medicinal Chemistry 1987, 30(12), 2283-2286) and 2,4-dichlorobenzylamine.

Sources & evidence

ORD record
ord-79ceeb818d1940f3938b77a8d241db62
Source dataset
uspto-grants-2009_08
Patent number
US07569563B2

Reaction notes

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