HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanatoacetate → N-{[(2RS,6SR)-4-(1-Cyclopropyl-3-{[(2,4-dichlorobenzyl)amino]carbonyl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinolin-7-yl)-2,6-dimethylpiperazin-1-yl]carbonyl}glycine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanatoacetate | HCID 76283 | — |
| Reactant | 1-Cyclopropyl-N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide | HCID 66859962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-{[(2RS,6SR)-4-(1-Cyclopropyl-3-{[(2,4-dichlorobenzyl)amino]carbonyl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinolin-7-yl)-2,6-dimethylpiperazin-1-yl]carbonyl}glycine ethyl ester | HCID 68976051 | — |
Reaction Steps
100 mg (0.18 mmol) of the compound from Example 39A are added to a solution of 25 mg (0.22 mmol) of ethyl isocyanatoacetate in 5 ml of dichloromethane. The reaction mixture is stirred at RT overnight. After the removal of the solvent on a rotary evaporator, the residue is purified by RP-HPLC (method 6). 73 mg (59% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569563B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-f74f1d042d284c309efeb6ae025bfe4e |
| Source note | uspto-grants-2009_08 |