Methyl iodide → Methyl 2,2-diphenylpropionate

Participants

Reaction Conditions

Reaction Steps

37.60 g (0.247 mol) of DBU are added dropwise to a suspension of 50.8 g (0.225 mol) of 2,2-diphenylpropionic acid and 200 mL of acetonitrile at 20° C. 70.10 g (0.494 mol) of methyl iodide are added dropwise to the resulting solution within 30 minutes. Then the mixture is stirred overnight at 20° C. The solvent is evaporated down, the residue is extracted with diethylether/water, the organic phase is washed with water, dried over Na2SO4, and evaporated to dryness. Yield: 48.29 g of viscous residue 3.1. (89% of theory).

Provenance & Evidence