HCID 68829179, compound → HCID 11607016, compound

Participants

Reaction Steps

0.21 g of tert-butyl 3-{[(1R)-1-(4-chlorobenzyl)-2-(3-{cyclohexyl[(diethylamino)carbonyl]amino}-8-azabicyclo[3.2.1]oct-8-yl)-2-oxoethyl]amino}-8-azabicyclo[3.2.1]octane-8-carboxylate is placed in 1.53 ml of 2N hydrochloric acid in diethyl ether. The reaction medium is stirred at ambient temperature overnight. Trituration, rinsing with diethyl ether, and filter-drying of the precipitate obtained are carried out. The crystals are then dried over P2O5 under reduced pressure. 0.12 g of N-[8-(N-8-azabicyclo[3.2.1]oct-3-yl-4-chloro-D-phenylalanyl)-8-azabicyclo[3.2.1]oct-3-yl]-N-cyclohexyl-N′,N′-diethylurea hydrochloride is obtained.

Provenance & Evidence