Potassium Sulfate → HCID 58777908, compound

Participants

Reaction Conditions

Reaction Steps

6.4 g of tert-butyl (3R)-3-({[(1R)-1-(4-chlorobenzyl)-2-methoxy-2-oxoethyl]amino}methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate are dissolved in 150 ml of a mixture of tetrahydrofuran/water/MeoH (1/1/1) at 0° C., and 0.99 g of lithium hydroxide hydrate is added. Stirring is maintained at 0° C. for 3 h. 0.5 g of lithium hydroxide hydrate is then added. The medium is maintained at 0° C. for 16 h. Potassium sulphate is added up to a pH of 7. The precipitate obtained is filter-dried and rinsed with diethyl ether. After drying over P2O5, 7.2 g of N-{[(3R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl}-4-chloro-D-phenylalanine are obtained.

Provenance & Evidence