HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester → 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester | HCID 86605432 | — |
| Reactant | (3-Morpholin-4-yl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 86606802 | — |
| Product | 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline | HCID 66775711 | — |
Reaction Steps
Utilising the procedure described in Example 90c but employing [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 91c) in lieu of [3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as a yellow crystalline solid, m.p. 130-133° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569566B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-fbdf424946bd4f4fafd99094105b0c34 |
| Source note | uspto-grants-2009_08 |