Chloroacetone → HCID 178431964, compound

HRID 2099523Notes

Reaction equation

HRID 2099523 reaction equation
[C:1]([NH:4][C:5]([NH2:7])=[S:6])(=[NH:3])[NH2:2].Cl[CH2:9][C:10](=O)[CH3:11]>CC(C)=O>[CH3:11][C:10]1[N:7]=[C:5]([NH:4][C:1]([NH2:2])=[NH:3])[S:6][CH:9]=1

Participants

4

Reactant 2

HCID 6571ChloroacetoneHCID 178513045HCID 178513045, compound

Product 1

HCID 178431964HCID 178431964, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of amidinothiourea (2.0 g, 16.9 mmol), chloroacetone (1.56 g, 16.9 mmol) was heated at reflux in acetone (12 mL) for 4 h. The mixture was cooled to room temperature and removed half of the solvent. The precipitate was filtered, washed with dry acetone, and dried to give N-(4-methyl-1,3-thiazol-2-yl)guanidine (2.19 g, 83%).

Workup

  1. temperaturewas heated
  2. customremoved half of the solvent
  3. filtrationThe precipitate was filtered
  4. washwashed with dry acetone
  5. customdried

Sources & evidence

ORD record
ord-b3f71b03ff254f51a95e6bf67ad050f6
Source dataset
uspto-grants-2009_08
Patent number
US07569596B2

Reaction notes

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