Diisopropylethylamine → HCID 59773102, compound

Participants

Reaction Steps

Diisopropylethylamine (427 mg) was added to a stirred solution of 2-methyl-5-phenyl-furan-3-carboxylic acid (334 mg, 1.6 mmol) and ethyl-4-aminophenyl acetate (296 mg, 1.65 mmoles) in N,N-dimethylformamide (30 ml). 0-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (628 mg, 1.65 mmoles) was added and the solution was stirred at room temperature for 18 hours. The solvent was evaporated, the residue was dissolved in dichloromethane and washed with water, 10% aqueous sodium carbonate, 1M aqueous hydrochloric acid and finally dried (MgSO4). After evaporation of the solvent, the residue was triturated with cyclohexane and dried to afford (4-[(2-Methyl-5-phenyl-furan-3-carbonyl)-amino]-phenyl}-acetic acid ethyl ester (1)(466 mg) as a gum. LC/MS System D; Rt=10.64 mins, m/z (ES+)=364 (M+H for C22H21NO4).

Provenance & Evidence