Cesium carbonate → HCID 59773096, compound

Participants

Reaction Steps

A solution of {4-[(5-Bromo-furan-3-carbonyl)-amino]-phenyl}-acetic acid ethyl ester (828 mg, 2.35 mmoles) (8), 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol (518 mg, 2.35 mmoles), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (50 mg) and 2M aqueous cesium carbonate (3.5 ml, 3.5 mmoles) in N,N-dimethylformamide (20 ml) was heated in a microwave reactor at 100° C. for 15 minutes. The solvent was evaporated, and the residue was purified by flash chromatography (gradient elution with 100% cyclohexane to 50% cyclohexane/50% ethyl acetate) to afford (4-{[5-(4-hydroxy-phenyl)-furan-3-carbonyl]-amino}-phenyl)-acetic acid ethyl ester (11) (328 mg). LC/MS System A; Rt=3.35 mins, m/z (ES+)=366 (M+H for C21H19NO5).

Provenance & Evidence