3-Furanmethanol, 5-(phenylmethyl)- → HCID 23634408, compound

Participants

Reaction Steps

Under nitrogen atmosphere, to a mixture of 0.50 g of 5-benzyl-3-furylmethyl alcohol, 0.62 g of (1R)-cis-2,2-dimethyl-3-((E)-3-ethoxy-2-fluoro-3-oxo-1-propenyl)-cyclopropanecarboxylic acid, 0.1 g of 4-dimethylaminopyridine and 7 ml of dichloromethane was added 0.60 g of N,N-dicyclohexylcarbodiimide, and the mixture was stirred at room temperature for 3 hours. Then, the reaction mixture was filtrated, and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to silica gel chromatography to obtain 0.69 g of 5-benzyl-3-furylmethyl (1R)-cis-2,2-dimethyl-3-((E)-3-ethoxy-2-fluoro-3-oxo-1-propenyl)cyclopropanecarboxylate (hereinafter, referred to as the present compound (1)).

Provenance & Evidence