Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-(1-benzylpyrrolidin-2-ylidene)(phenyl)acetate → Methyl phenyl(pyrrolidin-2-yl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-(1-benzylpyrrolidin-2-ylidene)(phenyl)acetate | HCID 68800975 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl phenyl(pyrrolidin-2-yl)acetate | HCID 22084928 | — |
반응 단계
To a solution of methyl 2-(1-benzylpyrrolidin-2-ylidene)(phenyl)acetate (0.505 g, 1.64 mmol) in 5 mL of methanol was added palladium(II) hydroxide (231 mg, 1.64 mmol), and the reaction was stirred under a balloon of hydrogen gas. After 3 days, the mixture was filtered through celite, the pad was rinsed with CH2Cl2/MeOH, and the filtrate was concentrated in vacuo to provide methyl phenyl(pyrrolidin-2-yl)acetate as a mixture of two diastereomers. ESI+MS: 220.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07569589B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-a943816242fc46a2934ac4797b3aab84 |
| 출처 메모 | uspto-grants-2009_08 |