HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dibutyltin dichloride → HCID 178499286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dibutyltin dichloride | HCID 12688 | — |
| Reactant | Phenylsilane | HCID 12752 | — |
| Reactant | 3-Amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester | HCID 57795435 | — |
| Reactant | 5-[1,2,4]Triazol-1-yl-heptan-2-one | HCID 67278637 | — |
| Product | HCID 178499286 | HCID 178499286 | 81.4% |
Reaction Steps
Reductive amination of 3-amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester (0.630 g, 2.37 mmol) and 5-[1,2,4]triazol-1-yl-heptan-2-one (0.560 g, 3.39 mmol) was performed under the same conditions previously described (example 3, step I) using dibutyltin dichloride and phenylsilane to give 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(trans-4-[1,2,4]triazol-1-yl-cyclohexylamino)-thiophene-2-carboxylic acid methyl ester (0.800 g, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569600B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-217bf567a3944959a8e51a5aa8c25382 |
| Source note | uspto-grants-2009_08 |