HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino)thiophene-2-carboxylic acid methyl ester → HCID 178499287, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino)thiophene-2-carboxylic acid methyl ester | HCID 57795476 | — |
| Reactant | HCID 178461265 | HCID 178461265 | — |
| Product | HCID 178499287 | HCID 178499287 | 60% |
Reaction Steps
5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(4-[1,2,4]triazol-1-yl-cyclohexylamino)thiophene-2-carboxylic acid methyl ester (0.800 g, 2 mmol) was acylated with with trans-4-methylcyclohexyl carboxylic acid chloride as previously described (example 1, step II) to give 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-[(trans-4-methyl-cyclohexanecarbonyl)-(4-[1,2,4]triazol-1-yl-cyclohexyl)-amino]-thiophene-2-carboxylic acid methyl ester (0.640 g, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569600B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-e56fa27a539f4c5a9739f3e6c1f4a6af |
| Source note | uspto-grants-2009_08 |