Formaldehyde → HCID 178499290, compound

HRID 2099673Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:25]2[CH2:30][CH2:29][C:28]([CH3:32])([CH3:31])[CH2:27][CH2:26]2)=[CH:8][C:9]=1[N:10]([CH:20]([CH2:23][OH:24])[CH2:21][OH:22])[C:11]([C@H:13]1[CH2:18][CH2:17][C@H:16]([CH3:19])[CH2:15][CH2:14]1)=[O:12])=[O:4].[CH2:33]=O>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:25]2[CH2:26][CH2:27][C:28]([CH3:31])([CH3:32])[CH2:29][CH2:30]2)=[CH:8][C:9]=1[N:10]([CH:20]1[CH2:23][O:24][CH2:33][O:22][CH2:21]1)[C:11]([C@H:13]1[CH2:14][CH2:15][C@H:16]([CH3:19])[CH2:17][CH2:18]1)=[O:12])=[O:4]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 178499291HCID 178499291, compound

Product 1

HCID 178499290HCID 178499290, compound

Procedure

5-(4,4-Dimethyl-cyclohexyl)-3-[[1,3]dioxan-5-yl-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester was prepared from 5-(4,4-dimethyl-cyclohexyl)-3-[(2-hydroxy-1-hydroxymethyl-ethyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester using paraformaldehyde following a procedure described earlier (example 38, step IV).

Sources & evidence

ORD record: ord-fc946dffaa484e178a2b731d45c754bc
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07569600B2

Reaction notes

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