HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 8-Azido-1,4-dioxaspiro[4.5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 1,4-Dioxaspiro(4.5)decan-8-yl methanesulfonate | HCID 14966741 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 8-Azido-1,4-dioxaspiro[4.5]decane | HCID 57424094 | 100.9% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of methanesulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester (2.80 g, 11.9 mmol) and sodium azide (3.86 g, 59.3 mmol) in 50 mL of dry DMF was stirred for 20 h at 100° C. under nitrogen. The final mixture was cooled to room temperature dilute with brine and extracted with three portions of ether. The organic portions were combined, dried over Na2SO4 and concentrated to give 8-azido-1,4-dioxa-spiro[4.5]decane (2.2 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569600B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-55bef0ee2a9c41e4942fe424dfbdfb0c |
| Source note | uspto-grants-2009_08 |