HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → [2-(2-carbamoyl-benzo[1,3]dioxol-5-yl)-1-methyl-ethyl]-ethyl-carbamic Acid Tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-[2-(tert-butoxycarbonyl-ethyl-amino)-propyl]-benzo[1,3]dioxole-2-carboxylic Acid Ethyl Ester | HCID 68900004 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [2-(2-carbamoyl-benzo[1,3]dioxol-5-yl)-1-methyl-ethyl]-ethyl-carbamic Acid Tert-Butyl Ester | HCID 68896083 | 96% |
Reaction Steps
To 2.04 g (5.37 mmol) of 2D was added 30 mL of anhydrous methanol, and ammonia gas was passed through the solution for 1 hour at room temperature. The mixture was concentrated to dryness and the residue purified by silica gel column chromatography using 30% hexane in ethyl acetate to give 1.8 g (5.13 mmol, 96%) of 2E as a colorless gum (M+Na, 373).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569676B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-f30fcc67d6514843bbfec1fdc59cf301 |
| Source note | uspto-grants-2009_08 |