反应详情

To 987 mg (2.1 mmol) of 2I was added 50 mL of anhydrous methanol followed by 150 mg of 10% Pd—C. This mixture was hydrogenated under atmospheric pressure 18 hours, filtered and the residue was washed with 50 mL of methanol. The combined filtrate was concentrated to dryness, and the residue was purified by silica gel column chromatography using 5% methanol in ethyl acetate to give 558 mg (1.67 mmol, 79%) of 2J as a colorless gum (M+H, 333).

1. customwas hydrogenated under atmospheric pressure 18 hours
2. filtrationfiltered
3. washthe residue was washed with 50 mL of methanol
4. concentrationThe combined filtrate was concentrated to dryness
5. customthe residue was purified by silica gel column chromatography