Lithium hydroxide, monohydrate → HCID 178436414, compound

Participants

Reaction Steps

A suspension of (±)-3-(7-ethyl-3-methyl-1H-indazol-5-yl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid methyl ester (0.94 g, 1.81 mmol) in 1:1 tetrahydrofuran/methanol (30 mL) at room temperature was treated with a solution of lithium hydroxide monohydrate in water (10 mL). The solution was stirred at room temperature for 1 hand the solvents evaporated. The resultant residue was diluted with water (10 mL) and the pH adjusted to ca. 1 with 1N hydrochloric acid. The resultant white suspension was stored at 4° C. overnight and the product was collected by filtration, washed by a small amount of water and dried in vacuo for several hours to give 0.82 g (90%) of the desired product. LC/MS: tR=1.57 min, 505.29 (MH)+.

Provenance & Evidence