Formic Acid → HCID 11752837, compound

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Reaction Steps

Solid (±)-1-(6-tert-butoxypyridin-2-yl)-2-(7-methyl-1H-indazol-5-yl)ethyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate (previous example) (20.6 mg) was treated with 1 mL formic acid (90%). After 2 h, the mixture was diluted with water and extracted three times with ethyl acetate. The combined organic layers were washed with water, saturated sodium bicarbonate solution, dried and concentrated. Further drying under high vacuum afforded the product (11.8 mg, 63.4%) as an off-white powder. MS (ESI) [M+H]+=527. HPLC tR=1.68 min.

Provenance & Evidence