Triphenylphosphine → HCID 57794658, compound

Participants

Reaction Steps

tert-Butyl 1-{2-(pyridin-2-yl)hydrazinyl}-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-ylcarbamate (70 mg, 0.17 mmol), triphenylphosphine (54 mg, 0.2 mmol), and trimethylsilyl azide (25 μL, 0.19 mmol) were combined in dry tetrahydrofuran (2.0 mL) at 0° C. Diethylazodicarbaoxylate (33 μL, 0.2 mmol) was added to the reaction mixture to afford a brown solution which was stirred at room temperature for 2 h. The solvents were removed in vacuo and the crude mixture purified by column chromatography to afford 45.2 mg (71%). Mass spec.: 393.04 (MH)+.

Provenance & Evidence