benzyl 2-(7-methyl-1H-indazol-5-yl)-1-(1-neopentyl-1H-tetrazol-5-yl)ethylcarbamate → HCID 57794577, compound

HRID 2099808Notes

Reaction equation

HRID 2099808 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:11][CH:12]([NH:23]C(=O)OCC2C=CC=CC=2)[C:13]2[N:17]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[N:16]=[N:15][N:14]=2)[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:11][CH:12]([C:13]2[N:17]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[N:16]=[N:15][N:14]=2)[NH2:23])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2

Participants

4

Reactant 1

HCID 57794590benzyl 2-(7-methyl-1H-indazol-5-yl)-1-(1-neopentyl-1H-tetrazol-5-yl)ethylcarbamate

Product 1

HCID 57794577HCID 57794577, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of benzyl 2-(7-methyl-1H-indazol-5-yl)-1-(1-neopentyl-1H-tetrazol-5-yl)ethylcarbamate (70.0 mg, 0.156 mmol) in methanol (2.0 mL) was flushed with nitrogen, and treated with palladium (10% on charcoal, 7.0 mg). The flask was flushed with hydrogen and allowed to stir under a balloon of hydrogen overnight. The reaction was flushed with nitrogen, filtered through celite, and concentrated. Column chromatography gave 48.0 mg (quant.). Mass spec.: 314.17 (MH)+.

Workup

  1. customThe flask was flushed with hydrogen
  2. customThe reaction was flushed with nitrogen
  3. filtrationfiltered through celite
  4. concentrationconcentrated
  5. customColumn chromatography gave 48.0 mg (quant.)

Sources & evidence

ORD record
ord-151f6b7c077445ec9832866edf7d9629
Source dataset
uspto-grants-2009_08
Patent number
US07569578B2

Reaction notes

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