HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Chloro-6-methylpyridin-4-yl)methanol | HCID 22504306 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-4-(chloromethyl)-6-methylpyridine | HCID 21698167 | — |
Reaction Steps
(2-Chloro-6-methylpyridin-4-yl)methanol (0.212 g, 1.35 mmol) and thionyl chloride (0.12 mL, 1.62 mmol) were combined in methylene chloride (4 mL) and stirred at room temperature for 4 h. The solvents were removed and the product dried under vacuum for several hours to afford 0.24 g (quant.) as a clear oil which was used without purification. Mass spec.: 176.0 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569578B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-2f6899c5c0574523b8288fa8836090b8 |
| Source note | uspto-grants-2009_08 |