Potassium Carbonate → HCID 69071449, compound

Participants

Reaction Steps

A mixture of tert-butyl 3-(1H-imidazol-2-yl)-4-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)butanoate (0.16 mmol), 4-tert-butylbenzyl bromide (1.0 equiv), and potassium carbonate (1.0 equiv) in dimethylformamide (2 mL) was stirred at room temperature overnight. The mixture was diluted with ethyl acetate (20 mL) and washed with water (3×5 mL). The ethyl acetate layer was dried, filtered and concentrated in vacuo. The product was obtained by flash chromatography using 0% to 50% ethyl acetate/hexane (65%). 1H-NMR (400 MHz, CDCl3) δ 7.93 (1H, s), 7.23 (2H, m), 7.03 (2H, m), 6.82 (2H, m), 6.63 (1H, s), 6.49 (1H,s), 5.68 (2H, s), 4.82 (2H, d, J=4.0 Hz), 3.60 (2H, t, 8.0 Hz), 3.41 (1H, m), 2.86 (2H, d, J=8.0 Hz), 2.79 (1H, dd, J1=8.0 Hz, J2=16 Hz), 2.61 (1H, dd, J1=8.0 Hz, J2=16 Hz), 2.49 (3H, s), 1.31 (9H, s), 1.25 (9H, s), 0.91 (2H, t, J=8.0 Hz), −0.06 (9H,s). MS(ESI)[M+H]+=617.

Provenance & Evidence