Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl morpholine oxide → HCID 178519309, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl morpholine oxide | HCID 82029 | — |
| 반응물 | HCID 178520873 | HCID 178520873 | — |
| 촉매 | HCID 178419074 | HCID 178419074 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178519309 | HCID 178519309 | 44% |
반응 단계
Into a dichloromethane solution (5 ml) of the compound (174 mg) obtained in Example 405 were added NMO (100 mg) and MS4A, followed by 10 minutes of stirring at room temperature. TPAP (8 mg) was further added thereto, followed by 30 minutes of stirring at room temperature. The reaction solution was purified by silica gel column chromatography (eluent: chloroform:methanol=40:1 (v/v)) to obtain 2-[1-(3,5-difluorobenzoyl)-2-oxo-2-phenylethylidene]-2,3-dihydro-1H-benzimidazol-5-carbaldehyde (76 mg, 44%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07569688B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-9a56a8d89079483d94ed9d258cb81d4d |
| 출처 메모 | uspto-grants-2009_08 |