Ethyl Acetate → HCID 178450401, compound

Participants

Reaction Steps

Solid K2CO3 (11.1 g, 80 mmol) was added to a solution of compound 10 (29.4 g, 38 mmol) in methanol (350 mL). After stirring at room temperature for 5 hours, mixture was poured into EtOAc, washed with aqueous NaHCO3, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to a yellow foam. Purification by silica gel chromatography (1% methanol in CH2Cl2) yielded 20.0 g (83%) of nucleoside 11 as a pale yellow foam.

Provenance & Evidence