Tetrabutylammonium Fluoride → HCID 15546052, compound

Participants

Reaction Steps

Compound 12 (13.2 g, 26.7 mmol) was dissolved in anhydrous THF (60 mL). To this mixture was added tetrabutylammonium fluoride (TBAF, 29.4 mmol, 29.4 mL of a 1 M solution in THF). After stirring at room temperature for 2 hours, mixture was concentrated in vacuo to ˜15 mL and then eluted through a short silica gel column with 10% methanol in CH2Cl2. Eluate was concentrated to a pale solid, which was washed on a glass frit with a minimal amount of ice-cold methanol. The remaining solid was dried in vacuo to yield 5.78 g (84%) of 13 as a white solid.

Provenance & Evidence