Hydrazine hydrate (1:1) → HCID 178424420, compound

Participants

Reaction Steps

To a solution of Compound 50 (15.9 g, 16.7 mmol) in anhydrous EtOH (500 mL) is added hydrazine hydrate (1.46 mL, 30.1 mmol). After stirring at room temperature for 3 hours, the mixture is concentrated in vacuo to ˜100 mL, then poured into EtOAc (500 mL) and washed with saturated aqueous NaHCO3 (2×100 mL). The organic phase is dried over anhydrous Na2SO4, filtered and evaporated. The crude Compound 51 is used without further purification

Provenance & Evidence