1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene) → HCID 131727559, compound

Participants

Reaction Steps

To a solution of Compound 67 (1.80 g, 3.54 mmol) in anhydrous pyridine (15 mL) was added 4-N,N-dimethylaminopyridine (65 mg, 0.53 mmol) and 4,4′-dimethoxytrityl chloride (2.04 g, 6.02 mmol). After stirring at room temperature for 6 hours the reaction mixture was quenched with methanol and concentrated in vacuo. The residue was dissolved in CH2Cl2 (300 mL), washed with saturated aqueous NaHCO3, dried over Na2SO4, filtered, and evaporated. Purification by silica gel chromatography (2% methanol in CH2Cl2) yielded 2.37 g (82%) of Compound 68 as a pale yellow foam.

Provenance & Evidence