Ammonium Chloride → HCID 57796670, compound

Participants

Reaction Steps

A solution of 49 mg (0.11 mmol) of tert-butyl 1-[1-(3-methylbut-2-enyl)-6-nitro-1H-benzimidazol-2-yl]hexahydropyrrolo[3,4-b]pyrrole-5-carboxylate in 7.5 ml of ethanol was added dropwise to a suspension of 62 mg (1.11 mmol) of iron and 11 mg (0.20 mmol) of ammonium chloride in 0.75 ml of water, and the mixture was boiled at reflux for 3 hours. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated under reduced pressure. The 43 mg of the desired product thus obtained were used in the next stage without further purification.

Provenance & Evidence