Acetic Anhydride → 1,3-Dioxooctahydroisobenzofuran-5-carboxylic acid

HRID 2099907Notes

Reaction equation

HRID 2099907 reaction equation
[CH:1]1([C:13]([OH:15])=[O:14])[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH:2]1[C:10]([OH:12])=O.C(OC(=O)C)(=O)C>C(O)(=O)C>[CH:1]12[C:13](=[O:14])[O:15][C:10](=[O:12])[CH:2]1[CH2:3][CH:4]([C:7]([OH:9])=[O:8])[CH2:5][CH2:6]2

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 11344952HCID 11344952, compound

Product 1

HCID 156855011,3-Dioxooctahydroisobenzofuran-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

Into a four-necked flask equipped with a thermometer, a stirrer, a condenser and a heat controller, were charged 100 parts of 1,2,4-cyclohexanetricarboxylic acid, 67 parts of acetic anhydride and 333 parts of glacial acetic acid. The contents were stirred for anhydrization at 120° C. for one hour under heating in a nitrogen gas flow. After cooling to 25° C., the precipitated crystals were separated by filtration and dried in a nitrogen gas flow to obtain a white, solid 1,2,4-cyclohexanetricarboxylic acid-1,2-anhydride.

Workup

  1. customInto a four-necked flask equipped with a thermometer, a stirrer, a condenser
  2. temperatureunder heating in a nitrogen gas flow
  3. temperatureAfter cooling to 25° C.
  4. customthe precipitated crystals were separated by filtration
  5. customdried in a nitrogen gas flow

Sources & evidence

ORD record
ord-2204f51883be4caab04ba602ac9644e9
Source dataset
uspto-grants-2009_08
Patent number
US07569708B2

Reaction notes

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