Methanol → HCID 68856340, compound

Participants

Reaction Steps

9.2 ml of boron tribromide in 40 ml of dichloromethane are slowly added at −70° C. to 13 g of 3-(4-methoxybenzoyl)isoxazole in 200 ml of dichloromethane and stirring is then carried out at room temperature for 3 days. Then, at 0° C., 50 ml of methanol are added dropwise thereto; concentration is carried out and the residue is stirred with 100 ml of 1N hydrochloric acid and 300 ml of ethyl acetate. After concentration of the organic phase and purification over silica gel, 3-(4-hydroxybenzoyl)isoxazole is obtained in the form of beige crystals, m.p: 125-127° C.

Provenance & Evidence