O-ethylhydroxylamine hydrochloride → HCID 76608212, compound

HRID 2099937Notes

Reaction equation

HRID 2099937 reaction equation
[Cl:1][C:2]1[CH:25]=[C:24]([O:26][CH2:27][CH:28]=[C:29]([Cl:31])[Cl:30])[CH:23]=[C:22]([Cl:32])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:17]2[CH:21]=[CH:20][O:19][N:18]=2)=O)=[CH:11][CH:10]=1.Cl.[CH2:34]([O:36][NH2:37])[CH3:35]>N1C=CC=CC=1>[CH2:34]([O:36][N:37]=[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][CH2:5][O:4][C:3]2[C:2]([Cl:1])=[CH:25][C:24]([O:26][CH2:27][CH:28]=[C:29]([Cl:31])[Cl:30])=[CH:23][C:22]=2[Cl:32])=[CH:10][CH:11]=1)[C:17]1[CH:21]=[CH:20][O:19][N:18]=1)[CH3:35]

Participants

4

Reactant 2

HCID 76850O-ethylhydroxylamine hydrochlorideHCID 86605427HCID 86605427, compound

Product 1

HCID 76608212HCID 76608212, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

486 mg of (4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-isoxazol-3-yl-methanone in 25 ml of pyridine are stirred with 184 mg of O-ethylhydroxylamine hydrochloride at 110° C. for 24 hours. The reaction mixture is concentrated and the residue is stirred with tert-butyl methyl ether and 0.5N hydrochloric acid. After concentration of the organic phase and purification over silica gel, the title compound is obtained.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customAfter concentration of the organic phase and purification over silica gel

Sources & evidence

ORD record
ord-f0fd432ba602449d8cb2d9a860bf2a3e
Source dataset
uspto-grants-2009_08
Patent number
US07569727B2

Reaction notes

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