Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diphenylamine | HCID 11487 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | HCID 57796676 | HCID 57796676 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69000985 | HCID 69000985 | — |
Reaction Steps
3.00 parts of 2-(7-bromo-9,9-diethyl-9H-fluoren-2-yl)-1-methyl-1H-pyrrole (22), 1.54 parts of diphenylamine, 1.14 parts of sodium tert-butoxide, 0.09 parts of Pd(dba)2, and 0.065 parts of tri-tert-butyl phosphine were added into 50 parts of toluene under stirring to obtain a mixture. Then, the mixture was heated to 80° C. and reacted for 8 hours. After the reaction was stopped by water, a product was extracted by diethyl ether, and then dehydrated by magnesium sulfate. After the solvent was removed, the product was purified by dichloromethane/hexane in a silica gel column to obtain the compound (23a) of the present example.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07569704B1 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-7d52e207622542d4bdcae275614728fc |
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| Source note | uspto-grants-2009_08 |
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