Sodium Bicarbonate → HCID 57794212, compound

Participants

Reaction Steps

2 N-hydrochloride/diethyl ether solution (20 ml) and 50% hydrous-10% palladium/carbon (1.00 g) were added to a solution of the compound of Example 96 (1.00 g) in ethanol (200 ml) and the mixture was stirred thoroughly under hydrogen atmosphere for 1 hour. The filtrate except a catalyst was neutralized with aqueous sodium bicarbonate, and then the solvent was distilled off. The obtained residue was partitioned between ethyl acetate and water, and then the organic layer was washed with saturated brine and dried over anhydride magnesium sulfate. The residue obtained by distilling off the solvent under the reduced pressure, was subject to NH-silica gel (manufactured by Fuji Silysia Chemical Ltd.) chromatography, and was recrystallized from methanol to give the title compound (0.80 g, 62%).

Provenance & Evidence