2-(1H-imidazol-2-yl)ethan-1-ol → HCID 57794259, compound

HRID 2099986Notes

Reaction equation

HRID 2099986 reaction equation
[F:1][C:2]1[CH:43]=[CH:42][CH:41]=[C:40]([F:44])[C:3]=1[CH2:4][N:5]1[C:10]2[S:11][C:12]([C:20]3[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH:29][CH2:30][CH3:31])=[O:28])=[CH:22][CH:21]=3)=[C:13]([CH2:14][N:15]([CH2:17][CH2:18]O)[CH3:16])[C:9]=2[C:8](=[O:32])[N:7]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:6]1=[O:39].[OH:45][CH2:46][CH2:47][C:48]1[NH:49][CH:50]=[CH:51][N:52]=1>>[F:44][C:40]1[CH:41]=[CH:42][CH:43]=[C:2]([F:1])[C:3]=1[CH2:4][N:5]1[C:10]2[S:11][C:12]([C:20]3[CH:21]=[CH:22][C:23]([NH:26][C:27]([NH:29][CH2:30][CH3:31])=[O:28])=[CH:24][CH:25]=3)=[C:13]([CH2:14][N:15]([CH2:17][CH2:18][N:49]3[CH:50]=[CH:51][N:52]=[C:48]3[CH2:47][CH2:46][OH:45])[CH3:16])[C:9]=2[C:8](=[O:32])[N:7]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:6]1=[O:39]

Participants

3

Reactant 2

HCID 150160802-(1H-imidazol-2-yl)ethan-1-olHCID 68893898N-(4-(1-(2,6-difluorobenzyl)-5-(((2-hydroxyethyl)(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-ethylurea

Product 1

HCID 57794259HCID 57794259, compoundYield 15%

Procedure

The similar reaction to that of Example 120 was performed using N-(4-(1-(2,6-difluorobenzyl)-5-(((2-hydroxyethyl)(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-ethylurea (135 mg, 0.218 mmol) and 2-(2-hydroxyethyl)imidazole (122 mg, 1.09 mmol) to give the title compound (23 mg, 15%) as colorless crystals.

Workup

  1. customThe similar reaction to that of Example 120

Sources & evidence

ORD record
ord-fd5df480c9454ab083b69b1fe4be0495
Source dataset
uspto-grants-2009_08
Patent number
US07569570B2

Reaction notes

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