Trifluoroacetic acid → HCID 11439992, compound

Participants

Reaction Steps

The general hydrolysis procedure, described for 195 was followed. Thus, 1,1-dimethylethyl(2E)-3-{4-[cycloheptylidene(3-hydroxyphenyl)methyl]-2-fluorophenyl}-2-propenoate (198) (0.380 g, 0.9 mmol) in CH2Cl2 was treated with TFA to afford 0.305 g (92%) of the title compound as an off-white foam. 1H NMR (300 MHz, CD3OD): δ 7.76 (d, J=15.9 Hz, 1H), 7.59 (appt, J=7.8 Hz, 1H), 7.18 (app t, J=7.8 Hz, 1H), 7.04 (br d, J=8.1 Hz, 1H), 6.94 (br d, J=11.7 Hz, 1H), 6.67-6.60(m, 3H), 6.56 (d, J=16.2 Hz, 1H), 2.34 (br s, 4H), 1.62 (br s, 8H). LCMS (ESI): m/z 365 (M−H)−. Anal. Calcd for C23H23FO3.1.5H2O, C, 70.38; H, 6.63; F, 4.84; Found: C, 69.96; H, 5.95; F, 4.73.

Provenance & Evidence