Acetone → HCID 12135314, compound

Participants

Reaction Steps

A mixture of 90 mg (0.31 mmol; 1 eq.) of (9), 198 mg (0.93 mmol; 3 eq.) of 3,4,5-trimethoxyphenyl-boronic acid, 0.6 mL of Na2CO3 2M aqueous solution and 19 mg (0.0016 mmol; 0.05 eq.) of Pd(Ph3P)4 in 4 mL toluene was refluxed for 2.5 h. The solution was then cooled down to room temperature, dried over anhydrous sodium sulfate and the crude mixture was passed through a short silica gel column to remove catalyst. The crude product was purified by chromatography on silica gel with Hexane/Acetone 8:2 to give 57 mg (0.15 mmol; 48%) of a yellow oil. Rf=0.17 in Hex./Acetone 8:2.

Provenance & Evidence