HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Pyridin-2-ylazetidine-3-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-cyano-3-(pyridin-2-yl)azetidine-1-carboxylate | HCID 57798310 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Pyridin-2-ylazetidine-3-carbonitrile hydrochloride | HCID 68827153 | 99% |
Reaction Steps
A sample of tert-butyl 3-cyano-3-pyridin-2-ylazetidine-1-carboxylate (I-2, 485 mg, 1.9 mmol) was treated with HCl (20 mL of a 4.0 M solution in dioxane) and stirred at room temperature for 2 h before being concentrated under reduced pressure to afford 3-pyridin-2-ylazetidine-3-carbonitrile hydrochloride (365 mg, 99%) which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572792B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-671f2fa7bf2642b289debb27f41ff610 |
| Source note | uspto-grants-2009_08 |