2,6-DIAMINO-3-(2,3,5-TRICHLOROPHENYL)-PYRAZINE → N-[6-amino-5-(2,3,5-trichlorophenyl)pyrazin-2-yl]isoxazole-3-carboxamide

HRID 2100345Notes

Reaction equation

HRID 2100345 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[N:2]1.[Cl:9][C:10]1[C:15]([Cl:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=1[C:18]1[C:19]([NH2:25])=[N:20][C:21]([NH2:24])=[CH:22][N:23]=1>>[NH2:25][C:19]1[N:20]=[C:21]([NH:24][C:6]([C:3]2[CH:4]=[CH:5][O:1][N:2]=2)=[O:8])[CH:22]=[N:23][C:18]=1[C:11]1[CH:12]=[C:13]([Cl:17])[CH:14]=[C:15]([Cl:16])[C:10]=1[Cl:9]

Participants

3

Reactant 2

HCID 99260012,6-DIAMINO-3-(2,3,5-TRICHLOROPHENYL)-PYRAZINEHCID 112864533-Isoxazolecarboxylic acid

Product 1

HCID 57799144N-[6-amino-5-(2,3,5-trichlorophenyl)pyrazin-2-yl]isoxazole-3-carboxamide

Procedure

N-[6-amino-5-(2,3,5-trichlorophenyl)pyrazin-2-yl]isoxazole-3-carboxamide was prepared by a method analogous to Method B, as described above for Example 2, using 3-isoxazolecarboxylic acid and 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine (Preparation 12).

Sources & evidence

ORD record
ord-1f85aa551c0a451c9a2e7c2c9ee2b0a3
Source dataset
uspto-grants-2009_08
Patent number
US07572797B2

Reaction notes

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