Trichloroisocyanuric Acid → 1-Bromo-2,3-dichloro-5-methoxybenzene

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Reaction Steps

1-Bromo-3-chloro-5-methoxybenzene (Preparation 16, 6.0 g, 27 mmol) and trichloroisocyanuric acid (2.3 g, 9.9 mmol) were stirred in dimethylformamide (100 ml) at 50° C. for 3 hours. n-Heptane was added and the mixture filtered to remove insoluble impurities. The mixture was then concentrated in vacuo and the residue purified by silica gel column chromatography, eluting with n-heptane:ethyl acetate 9:1, to afford the title product as a white solid (5.0 g).

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