Sodium Hydroxide → HCID 68829652, compound

Participants

Reaction Steps

Methyl 3-[2-(N,N-dimethylamino)ethoxy]-4-iodobenzoate (Intermediate 3) (100 mg) was stirred in methanol (2 ml) and sodium hydroxide solution (2N, 2 ml) for 6 hours at room temperature. The methanol was evaporated under vacuum and the remaining solution neutralised with hydrochloric acid (2M). The mixture was extracted with ethyl acetate/chloroform (1:1) and the organic extracts reduced to dryness under vacuum to give 3-[2-(N,N-Dimethylamino)ethoxy]-4-iodobenzoic acid.

Provenance & Evidence