Methanol → Methyl 4-Bromo-3-hydroxybenzoate

Participants

Reaction Steps

4-Bromo-3-hydroxybenzoic acid (1 g) was dissolved in methanol (25 ml), concentrated sulphuric acid (165 μl) added and the reaction heated at reflux for 16 hours under nitrogen. The solvent was evaporated and ethyl acetate:chloroform (1:1, 100 ml) added. The solution was neutralised using aqueous sodium hydroxide solution (2M), washed with water (2×100 ml), dried using a hydrophobic filter and the solvent evaporated to leave methyl 4-bromo-3-hydroxybenzoate as a white solid (1.04 g).

Provenance & Evidence