Sodium Bicarbonate → HCID 9890142, compound

Participants

Reaction Steps

N-Cyclopropylmethyl-3-[2-(dimethylarnino)ethoxy]4-iodobenzamide (Intermediate 1) (42 mg), N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (38 mg), tetrakis(triphenylphosphine)palladium (2 mg) and aqueous sodiumhydrogen carbonate (1M, 0.3 ml) were reacted in propan-2-ol (2 ml) at 9° C. for 20 hours. The solvent was evaporated under vacuum and the residue purified by bond-elut (silica, 10 g) eluting with a methanol/chloroform gradient (1-10% methanol) to give, after evaporation of the solvents, N3-cyclopropyl-N4′-(cyclopropylmethyl)-2′-[2-(dimethylamino)ethoxy]-5-fluoro-6-methyl-1,1 ′-biphenyl-3,4′-dicarboxamide.

Provenance & Evidence