1,4-Dioxa-8-azaspiro(4.5)decane → 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxamide

Participants

Reaction Steps

To a stirred solution of 1,4-dioxa-8-azaspiro[4,5]-decane (1.1 g, 7.67 mmol) in isopropanol (20 mL) at rt was added trimethylsilylisocyanate (1.5 mL, 10.6 mmol) and the resulting solution stirred overnight before the volatiles were removed in vacuo to give 1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid amide (1.47 g, quant.); 1H-NMR (300 MHz, d6-DMSO) 5.96 (2H, s), 3.88 (4H, s), 3.33 (4H, t), 1.51 (4H, t).

Provenance & Evidence